Stephen R. Southworth, M.D.


  • Bachelor of Arts, 1979 – College of Wooster
  • Master of Science, 1981 – University of South Carolina
  • Doctor of Medicine, 1985 – Medical College of Ohio
  • Masters of Business Administration, 2013 – University of Tennessee

Specialized Surgeries

  • Fracture care
  • Joint Replacement
  • Sports Medicine


  • Rancho Los Amigos Medical Center, Downey, California


Medical College of Ohio and Affiliated Hospitals


Medical College of Ohio and Affiliated Hospitals

Medical School

Medical College of Ohio


  • American Board of Orthopaedic Surgery 1993
  • Certified 2003 & 2013, participating in Maintenance of Certification

Honors & Awards

  • Best Doctors in America: Southeast Region, 1996-97
  • Best Doctors in America: 1998-99, (4th edition)
  • Best Doctors in America: 2001-2004
  • U.S. Army Commendation Medal (El Salvador)
  • U.S. Army Commendation Medal (Peru)
  • NMMC Acute Rehabilitation Physician of the Year, 2004
  • Centers for Medicare & Medicaid Services Evidence Based Leader NMMC, 2012
  • Phi Kappa Phi Honor Society
  • Physician Preceptor of the Year NMHS Nurse Practioner Fellowship, 2022

Tupelo (Main Location)
499 Gloster Creek Village, Suite G1
Tupelo, MS 38801

Phone : 662-377-2663

Hip and Knee Replacement Specialist

Dr. Steve Southworth specializes in the treatment of hip and knee osteoarthritis. He is a board-certified orthopaedic surgeon offering non-surgical as well as surgical care of arthritis. He primarily concentrates in total hip replacement, knee replacement and ankle replacement. He also specializes in fracture care. He is a diplomate of the National Board of Medical Examiners.

He is Chairman of the Institutional Review Board for NMHS Research Medical Director for NMHS Physician Leadership Institute and Advanced Practioner Course.

Dr. Southworth enjoys his time bicycling and being a commercial pilot.

Meet Dr. Southworth

Professional Memberships

  • American Academy of Orthopaedic Surgeons (AAOS)
  • American College of Surgeons (FACS)
  • American Medical Association (AMA)
  • Association of Military Surgeons (AMSUS)
  • Mississippi Orthopaedic Society (MOS)
  • Shands Circle, OREF
  • Society of Military Orthopaedic Surgeons (SOMOS)


  • Effects of Verapamil and Lidocaine in a Canine Model of Sudden Death; J Am Coll Cardiol 6: 674-81, 1985 (co-author)
  • Asymptomatic Innominate Vein Tamponade with Retromanubrial Clavicular Dislocation: A Case Report; Orthop Rev XVII (8), 789-91, 1988, (author)
  • Cigarette Smoking and Dupuytren’s Contracture of the Hand; J Hand Surg 13A (6) 872-74, 1988 (co-author)
  • Intraneural Foreign Body of the Median Nerve: A complication of Acupuncture; J Hand Surg 15-B, 1:111-12, 1991 (author)
  • Compartment Syndrome as a Presentation of Non-Hodgkin’s Lymphoma; J Orthop Trauma 4(4): 470-73, 1990 (author)
  • Plating of the Fibula: Its Potential Value as an Adjunct to External Fixation of the Tibia; Clin Orthop 266: 209-13, 1991 (co-author)
  • Be Kind to Your Spine: Broward Sun-Sentinel: 8 Sep 1991 (author)
  • Pediatric Lumbar Seat Belt Injuries; Orthopedics 14(9): 1010-13, 1991 (co-author)
  • Conversion of Hip Arthrodesis to Total Joint Arthroplasty; Contemp Orthop 30(1) 37-42, 1995 (co-author)
  • C.D.H. No Longer S.O.P.; Biomechanics (letter) June 1997 Medical Readiness Training Exercise in El Salvador, Central America; Militar Med, 163, 8:519-23, 1998 (co-author)
  • Rapidly Progressive Osteoarthritis of the Hip. Clinical Challenges in Osteoarthritis and Viscosupplementation 1(1); 4-5, 2000 (author)
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Ibuprofen for the Management of Postoperative Pain in Adults. September ’09, Clin Ther 31(9); 1922-35 (author)
  • Latest Nailing Tips & Techniques: Innovations in Trauma and Hip Fracture Surgery. Webinar at, September, 2011 (co-author)
  • The Role of Intravenous NSAIDS in the Multimodal Management of Postoperative Pain. In “Analgesics: New Research”. Editors: Vivian Jacobs and Alexander Lang ISBN: 978-1-62100-674-9 2012 NOVA Science publishers (author)
  • The Effects of Nonsteroidal Anti-inflammatory Drugs on Clinical Outcomes, Synovial Fluid Cytokine Concentration and Signal Transduction Pathways in Knee Osteoarthritis. A Randomized Open Label Trial. Osteoarthritis and Cartilage 21 (2013) 1400-1408 (coauthor)
  • The Core Competencies for General Orthopaedic Surgeons JBJS Jan 18, 2017, Vol 99 (2) pp175-181; Task Force Member for spine care and knee arthroscopy
  • An Integrated Safety Analysis of Intravenous Ibuprofen (Caldolor) in Adults. Dove Press 2015:18, 753-765 (author)
  • A Novel Use of Growth Factors, CD34 Positive Cells, and Fibrin for Fingertip Injury: Description of a Case. Journal of Dermatology & Dermatologic Surgery 20 (2016) 62–64 (co-author)
  • Use of IV Ibuprofen Can Reduce Opioid Related Side Effects Anesthesiology News March, 27, 2020 (author)
  • Narrative Summary of Recently Published Literature on Intravenous Ibuprofen. Clin Ther 42(7), June 3, 2020
  • An Orthopaedic Surgeon, A Bike Wreck and Stopping the Cycle of Opioid Use. Webinar @ On Medical Grounds, E1, 2021
  • A Painful Problem. Webinar @ On Medical Grounds E23, 2022.


  • American Academy of Orthopaedic Surgeons
  • American College of Surgeons
  • American Medical Association
  • Association of Military Surgeons of the United States
  • Mississippi Orthopaedic Society
  • Shands Circle, OREF
  • Society of Military Orthopaedic Surgeons


  • Castle Connolly Top Doctors since 1999-present
  • American Board of Orthopaedic Surgery Content Expert 2022